Preparation of complex chitosan microcapsule and its application in controlled release of vitamin D2 / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 26-29, 2003.
Article
de Zh
| WPRIM
| ID: wpr-340923
Bibliothèque responsable:
WPRO
ABSTRACT
In this work a system which consists of chitosan (CS) microcores entrapped within enteric polymer is presented. Vitamin D2, used as a model drug, was efficiently entrapped within CS microcores using spray-drying and then microencapsulated into ethylic cellulose(EC). The morphology and release properties of microcapsules were tested. The influential factors of preparation conditions included molecular weight of chitosan, concentration of chitosan solution, concentration of acetic acid, loading of vitamin D2 were discussed. The results of in vitro release studies showed that the microcapsules prepared in this article could realize sustained release in intestine.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Techniques in vitro
/
Capsules
/
Cellulose
/
Chitine
/
Ergocalciférol
/
Systèmes de délivrance de médicaments
/
Préparations à action retardée
/
Chitosane
/
Préparation de médicament
Type d'étude:
Prognostic_studies
langue:
Zh
Texte intégral:
Journal of Biomedical Engineering
Année:
2003
Type:
Article