Coumarins from Leonurus japonicus and their anti-platelet aggregative activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4356-4359, 2014.
Article
Dans Zh
| WPRIM
| ID: wpr-341854
Responsable en Bibliothèque :
WPRO
ABSTRACT
Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18. Structures of the isolates were determined by spectroscopic analysis as 10 coumarins bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), murrayone(8) , auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time. In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Plaquettes
/
Antiagrégants plaquettaires
/
Chimie
/
Agrégation plaquettaire
/
Coumarines
/
Leonurus
langue:
Zh
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2014
Type:
Article