Application of array comparative genomic hybridization analysis for fetuses with growth anomalies / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 691-694, 2017.
Article
de Zh
| WPRIM
| ID: wpr-344194
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the genetic etiology for fetuses featuring intrauterine growth anomalies using array-based comparative genomic hybridization (aCGH).</p><p><b>METHODS</b>Forty-nine fetuses were enrolled in this study. Genomic DNA of the abortive tissues was analyzed with aCGH.</p><p><b>RESULTS</b>Fourteen (28.6%) samples were found with chromosomal aberrations, which included 8 chromosomal aneuploidies and 6 micro-aberrations (4 with known clinical pathogenecity and 2 with unknown clinical significance).</p><p><b>CONCLUSION</b>Numerical and structural chromosomal aberrations underlie a significant proportion of fetal growth anomalies. aCGH has provided an effective method for delineating their genetic cause.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Diagnostic prénatal
/
Malformations
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Aberrations des chromosomes
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Hybridation génomique comparative
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Variations de nombre de copies de segment d'ADN
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Génétique
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Méthodes
Type d'étude:
Diagnostic_studies
Limites du sujet:
Adult
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Female
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Humans
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Pregnancy
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2017
Type:
Article