Relationship between various Chinese medicine types and T-cell subsets in patients with ulcerative colitis / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 220-223, 2009.
Article
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| WPRIM
| ID: wpr-345010
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between various Chinese medicine (CM) types and T-cell subsets (CD4(+) and CD8(+)) in the colonic mucous membranes of patients with ulcerative colitis (UC).</p><p><b>METHODS</b>Fifty UC patients were enrolled, after differentiation into four types by CM syndromes, i.e., the internal heat-damp accumulation type (IHDA), the qi-stagnancy with blood stasis type (QSBS), the Pi-Shen yang-deficiency type (PSYD) and the yin-blood deficiency type (YBD). From every patient, 3-5 pieces of intestinal mucous membrane tissues were taken through colonoscopy to determine the levels of the T-cell subsets (CD4(+) and CD8(+)) using immunohistochemical method. The results were compared with those in the normal control.</p><p><b>RESULTS</b>The level of CD8(+)increased and the ratio of CD4(+)/CD8(+)decreased mainly in colonic mucous membranous tissues in UC patients. The level of CD4(+)decreased significantly in IHDA types (P<0.01), but decreased only slightly in the PSYD, QSBS and YBD types. CD8(+)increased significantly in the IHDA types (P<0.01), but only slightly in the other three types.</p><p><b>CONCLUSION</b>The IHDA types of UC are closely related with T-cell subsets. The difference of T-cell subsets in various IHDA types of UC patients has provided a theoretical basis for syndrome differentiation in the CM typing of UC.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Biopsie
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Circulation sanguine
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Immunohistochimie
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Rectocolite hémorragique
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Sous-populations de lymphocytes T
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Coloscopie
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Déficit du Yin
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Déficit du Yang
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Rapport CD4-CD8
Type d'étude:
Diagnostic_studies
Limites du sujet:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
langue:
En
Texte intégral:
Chinese journal of integrative medicine
Année:
2009
Type:
Article