Expression profile of TGF-β1 and BMP-7 in serum of preterm infants with respiratory distress syndrome / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 445-448, 2015.
Article
Dans Zh
| WPRIM
| ID: wpr-346130
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression profile and significance of serum transforming growth factor-beta 1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) in preterm infants with respiratory distress syndrome (RDS).</p><p><b>METHODS</b>Thirty-two preterm infants with RDS who were given pulmonary surfactant (PS) within 12 hours after birth were enrolled as the PS group. Twenty-eight preterm infants with RDS who were not given PS were selected as the non-PS group. Another 30 preterm infants without RDS were used as the control group. Serum levels of TGF-β1 and BMP-7 in the three groups were measured using enzyme-linked immunosorbent assay at 0, 1, 3, and 7 days after birth.</p><p><b>RESULTS</b>The PS group had higher serum levels of TGF-β1 than the control group at 1 and 3 days after birth (P<0.05). The non-PS group had significantly higher serum levels of TGF-β1 than the control group at 1, 3, and 7 days after birth (P<0.05), and serum levels of TGF-β1 in the non-PS group were significantly higher than the PS group at 3 and 7 days after birth (P<0.05). The PS group had higher serum levels of BMP-7 than the control group at 1 and 3 days after birth (P<0.05). The non-PS group had higher serum levels of BMP-7 than the control group at 1, 3, and 7 days after birth (P<0.05). The levels of BMP-7 in the non-PS group at 7 days after birth were reduced than before, but were still higher than in the PS group (P<0.05).</p><p><b>CONCLUSIONS</b>Both serum TGF-β1 and BMP-7 levels increase in the early stage in preterm infants with RDS, however, in the late stage, the expression of BMP-7 decreases with the increase in TGF-β1 expression, suggesting that administration of exogenous BMP-7 may reduce the expression of TGF-β1, which might be a therapeutic approach for RDS in preterm infants.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Syndrome de détresse respiratoire du nouveau-né
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Sang
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Prématuré
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Facteur de croissance transformant bêta-1
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Protéine morphogénétique osseuse de type 7
Limites du sujet:
Female
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Humans
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Male
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Newborn
langue:
Zh
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2015
Type:
Article