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Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism / 中国中药杂志
Zhongguo Zhong Yao Za Zhi ; (24): 1816-1819, 2013.
Article de Zh | WPRIM | ID: wpr-346493
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism.</p><p><b>METHOD</b>Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group, the model group, the psoralidine low-dose group (4 mg x kg(-1)), the psoralidine high-dose group (16 mg x kg(-1)) and the Zhuangguzhitong capsule group, with 12 rats in each group. Thirteen weeks later, their blood and bone samples were collected to detect bone density, bone biochemistry, pathomorphology, serum E2 and CT.</p><p><b>RESULT</b>Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy (P < 0.05), the maximum bending strength of thighbone (P < 0.05), and serum E2 and CT (P < 0.05).</p><p><b>CONCLUSION</b>Psoralidine has a good active effect on postmenopausal antiosteoporosis. Its mechanism may be related to such pathways as E2 and CT.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Benzofuranes / Sang / Médicaments issus de plantes chinoises / Densité osseuse / Ostéoporose post-ménopausique / Rat Sprague-Dawley / Coumarines / Traitement médicamenteux / Oestradiol Limites du sujet: Animals / Female / Humans langue: Zh Texte intégral: Zhongguo Zhong Yao Za Zhi Année: 2013 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Benzofuranes / Sang / Médicaments issus de plantes chinoises / Densité osseuse / Ostéoporose post-ménopausique / Rat Sprague-Dawley / Coumarines / Traitement médicamenteux / Oestradiol Limites du sujet: Animals / Female / Humans langue: Zh Texte intégral: Zhongguo Zhong Yao Za Zhi Année: 2013 Type: Article