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Chemical constituents of Periploca forrestii and their cytotoxicity activity / 中国中药杂志
Zhongguo Zhong Yao Za Zhi ; (24): 3214-3216, 2009.
Article de En | WPRIM | ID: wpr-346914
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of the roots of Periploca forrestii and evaluate their cytotoxicity activities.</p><p><b>METHOD</b>Silica gel column chromatography was employed for the isolation and purification of chemical constituents. The structures were identified on the basis of spectral data and the cytotoxicities of compounds 2-4 were investigated by several tumors cell lines including blood tumor (HL-60, CCRT-CEM), prostate tumor (PC-3, DU-145) and Melanoma (UACC-62).</p><p><b>RESULT</b>Four compounds were isolated and identified as follows, lupeol-20(29)-en-3-nonadecanoate (1), peroiforoside I (2), 3beta,5beta,14beta-3OH-8beta-H-car-20(22)-enolide (3), perplocin (4).</p><p><b>CONCLUSION</b>Compound 1 is a new lupane triterpene fatty acid ester. Compounds 2-4 showed notable cytotoxicity against all tumor lines.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pharmacologie / Triterpènes / Médicaments issus de plantes chinoises / Structure moléculaire / Survie cellulaire / Chimie / Racines de plante / Cellules HL-60 / Concentration inhibitrice 50 / Periploca Limites du sujet: Humans langue: En Texte intégral: Zhongguo Zhong Yao Za Zhi Année: 2009 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pharmacologie / Triterpènes / Médicaments issus de plantes chinoises / Structure moléculaire / Survie cellulaire / Chimie / Racines de plante / Cellules HL-60 / Concentration inhibitrice 50 / Periploca Limites du sujet: Humans langue: En Texte intégral: Zhongguo Zhong Yao Za Zhi Année: 2009 Type: Article