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Autophagy and hypoxic ischemic brain injuries / 生理学报
Sheng Li Xue Bao ; (6): 316-324, 2017.
Article de Zh | WPRIM | ID: wpr-348268
Bibliothèque responsable: WPRO
ABSTRACT
Autophagy is a highly evolutionarily conserved physiological mechanism of organism, including several stages such as autophagosomes formation, the fusion of lysosomes and autophagosomes, and autophagosomes degradation. In physiological conditions, autophagy is responsible for clearing the spoiled organelles and long-lived proteins to maintain the homeostasis of cells and organism. Meanwhile, autophagy is also involved in the formation and development of diseases, but the mechanism has not been confirmed yet. The relationship between autophagy and hypoxic ischemic brain injuries represented by stroke is a research hotpot in recent years, but there is no clear conclusion about autophagy's role and mechanism in hypoxic ischemic brain injuries. We reviewed the activation, function and mechanism of autophagy in hypoxic ischemic brain injuries, in order to provide some perspectives on these researches.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Autophagie / Hypoxie-ischémie du cerveau / Homéostasie / Lysosomes Limites du sujet: Animals / Humans langue: Zh Texte intégral: Sheng Li Xue Bao Année: 2017 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Autophagie / Hypoxie-ischémie du cerveau / Homéostasie / Lysosomes Limites du sujet: Animals / Humans langue: Zh Texte intégral: Sheng Li Xue Bao Année: 2017 Type: Article