Effects of acupuncture on expressions of transcription factors NF-E2, YB-1, LRG47 in the SAMP10 mouse / 中国针灸
Zhongguo zhenjiu
; (12): 651-654, 2006.
Article
de Zh
| WPRIM
| ID: wpr-348476
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of acupuncture in delaying aging.</p><p><b>METHODS</b>Using SAMP10 mice and normal control SAMR1 as model and applying RT-PCR and DIG probed Northern blot techniques to observe expression of NF-E2, YB-1, LRG47 genes in whole brain, cortex and hippocampus in the 8-month SAMR1 control group, 8-month SAMP10 control group, 8-month SAMP10 acupuncture group and 8-month SAMP10 non-point acupuncture group.</p><p><b>RESULTS</b>In the SAMP10 control group, the expression of NF-E2, YB-1 and LRG47 were down-regulated in the whole brain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal.</p><p><b>CONCLUSION</b>Aging of the SAMP10 mouse brain is related with expression of NF-E2, YB-1 and LRG47 genes, and acupuncture can regulate the expression of NF-E2, YB-1 and LRG47 genes, improving the functions of erythrocyte series, increasing proliferation of cells and immune function of cells in anti-bacteria, hence anti-aging.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Encéphale
/
Vieillissement
/
ARN messager
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Thérapie par acupuncture
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Régulation de l'expression des gènes
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Protéines G
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Protéine-1 de liaison à la boîte Y
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Sous-unité p45 du facteur de transcription NF-E2
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Génétique
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Métabolisme
Type d'étude:
Prognostic_studies
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Zhongguo zhenjiu
Année:
2006
Type:
Article