Analysis of prognostic factors in patients with hepatocellular carcinoma (≤5 cm) underwent hepatectomy / 中华外科杂志
Chinese Journal of Surgery
; (12): 89-93, 2016.
Article
Dans Zh
| WPRIM
| ID: wpr-349227
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical and pathological factors influencing the prognosis of patients with hepatocellular carcinoma (HCC)(≤5 cm) after hepatectomy.</p><p><b>METHODS</b>Two hundreds and nineteen cases with HCC(≤5 cm) undergoing hepatectomy in Cancer Hospital, Chinese Academy of Medical Sciences between December 2003 and July 2013 were collected. The alpha fetoprotein (AFP) level, tumor number, tumor size (diameter), liver cirrhosis, vascular invasion, capsular invasion, differentiation, surgical methods, resection margin, the way of treatments, the situation of recurrence and time to recurrence were analyzed. Log-rank test and the stepwise Cox proportional-hazards models were used to compare the prognosis, respectively.</p><p><b>RESULTS</b>The 1-, 3-, 5- and 10- year overall survival rates were 95.9%, 85.3%, 67.8% and 53.3% respectively in all patients.Single factor analysis indicated that vascular invasion, capsular invasion, tumor size, hepatic vascular occult, liver cirrhosis, tumor differentiation, AFP, the way of treatments, the situation of recurrence and time to recurrence can affect the prognosis significantly (all P<0.05). The multifactor analysis showed that AFP, tumor differentiation, liver cirrhosis, capsular invasion, tumor size and the situation of recurrence and time to recurrence were independent prognostic factors (all P<0.05).</p><p><b>CONCLUSION</b>The prognosis of patients with HCC(≤5 cm) underwent hepatectomy are affected by multi-factors, such as AFP, tumor differentiation, liver cirrhosis, capsular invasion, tumor size and the situation of recurrence and time to recurrence.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Pronostic
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Chirurgie générale
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Alphafoetoprotéines
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Modèles des risques proportionnels
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Taux de survie
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Études rétrospectives
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Carcinome hépatocellulaire
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Diagnostic
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Hépatectomie
Type d'étude:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Surgery
Année:
2016
Type:
Article