High Levels of Antibodies to Plasmodium falciparum Liver Stage Antigen-1 in Naturally Infected Individuals in Myanmar
The Korean Journal of Parasitology
; : 195-198, 2008.
Article
Dans En
| WPRIM
| ID: wpr-35027
Responsable en Bibliothèque :
WPRO
ABSTRACT
Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 serum samples from 116 infected individuals, and IgG responses to PfLSA-1 principally composed of responses of IgG1 and IgG3 subclasses. These results show that PfLSA-1 elicits effective antibody responses in individuals infected with P. falciparum, and thus it could be not only an attractive candidate protein for vaccine development, but also a useful antigen for serodiagnosis of the infection.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Immunoglobuline G
/
Anticorps antiprotozoaires
/
Paludisme à Plasmodium falciparum
/
Myanmar
/
Antigènes de protozoaire
Limites du sujet:
Animals
/
Humans
Pays comme sujet:
Asia
langue:
En
Texte intégral:
The Korean Journal of Parasitology
Année:
2008
Type:
Article