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Expression of hippocampus Klotho protein and insulin-like growth factor-1 in rats with dementia / 生物医学工程学杂志
J. biomed. eng ; Sheng wu yi xue gong cheng xue za zhi;(6): 808-811, 2013.
Article de Zh | WPRIM | ID: wpr-352161
Bibliothèque responsable: WPRO
ABSTRACT
This study aims to assess the expression of Klotho and insulin-like growth factor-1 (IGF-1) and the association between Klotho and IGF-1 in rats with dementia model. Thirty rats were randomly divided into three groups. Morris water maze was used to investigate the learning and memory functions, and enzyme linked immunosorbent assay was used to analyze the levels of Klotho and IGF-1. Klotho and IGF-1 levels in the model group were lower than those in other 2 groups. Morris water maze test showed that the model group had longer escape latency times and shorter step platform times compared to other groups. Line correlation model demonstrated that Klotho level was positively correlated with IGF-1 level in rats with dementia (P= 0. 029). The levels of Klotho and IGF-1 both reduced at hippocampus in rats with dementia model, suggesting that it may be a close relationship between Klotho and IGF-1 in the pathogenesis of dementia.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Physiologie / Facteur de croissance IGF-I / Rat Wistar / Apprentissage du labyrinthe / Démence / Génétique / Glucuronidase / Hippocampe / Mémoire / Métabolisme Type d'étude: Prognostic_studies Limites du sujet: Animals langue: Zh Texte intégral: J. biomed. eng / Sheng wu yi xue gong cheng xue za zhi Année: 2013 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Physiologie / Facteur de croissance IGF-I / Rat Wistar / Apprentissage du labyrinthe / Démence / Génétique / Glucuronidase / Hippocampe / Mémoire / Métabolisme Type d'étude: Prognostic_studies Limites du sujet: Animals langue: Zh Texte intégral: J. biomed. eng / Sheng wu yi xue gong cheng xue za zhi Année: 2013 Type: Article