Expression of telomere repeat binding factor 1 (TRF1) protein in kidney cancer / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 496-508, 2004.
Article
Dans Zh
| WPRIM
| ID: wpr-353274
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression levels of telomere repeat binding factor 1(TRF1) protein in normal kidney tissue and kidney cancer.</p><p><b>METHODS</b>Specimens of kidney cancer and pericancerous tissues were collected from 32 cases of renal carcinoma. A quantitative Western blotting technique was developed using TRF1 monoclonal antibody to determine the expression level of TRF1 protein in total protein extracts from tissue specimens.</p><p><b>RESULTS</b>The expression level of TRF1 protein was higher in normal kidney tissues (3.611 +/-1.922 microg/microl) than that of cancer tissues (2.428 +/-1.352 microg/microl) (t=5.776, P<0.01).</p><p><b>CONCLUSION</b>The expression level of TRF1 protein is significantly reduced in kidney cancer and the level is negatively correlated with malignant degree of the cancer.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
ARN messager
/
Adénocarcinome à cellules claires
/
Protéine-1 se liant aux répétitions télomériques
/
Génétique
/
Rein
/
Tumeurs du rein
/
Métabolisme
Limites du sujet:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2004
Type:
Article