Molecular epidemiology of serotype 19A Streptococcus pneumoniae isolated from children in Beijing, 1997-2006 / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1769-1774, 2011.
Article
Dans En
| WPRIM
| ID: wpr-353931
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Despite the prevalence of Streptococcus pneumoniae serotype 19A, the molecular characteristics of this serotype are yet to be fully elucidated. The aim of this study was therefore to determine the homology of the serotype 19A in China.</p><p><b>METHODS</b>Pulsed-field gel electrophoresis and multilocus sequence typing were done to these forty-nine serotype 19A isolates to investigate the relationship between the strains prevalent in Beijing and other regions.</p><p><b>RESULTS</b>From 1997 to 2006, the percentage of serotype 19A isolates increased. The susceptibility rate to penicillin and amoxicillin decreased and the resistance rate to cefuroxime increased. ST320 was the most prevalent ST, followed by ST3546. There were six new STs identified in our study. The serotype 19A strains were classified into six different pulsed-field gel electrophoresis (PFGE) patterns. ST320, which was associated with two different PFGE patterns (A and D), accounted for 32 isolates, and ST3546, which was associated with two PFGE patterns (B and E), accounted for eight isolates.</p><p><b>CONCLUSIONS</b>From 2003 onwards, ST320 was the most common ST and the rate of resistance to cefuroxime increased significantly. Further long-term surveys of Streptococcus pneumoniae serotype 19A are required to monitor ST prevalence and antimicrobial resistance in this important human pathogen.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Infections à pneumocoques
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Streptococcus pneumoniae
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Facteurs temps
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Sérotypie
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Chine
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Classification
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Électrophorèse en champ pulsé
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Épidémiologie moléculaire
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Résistance bactérienne aux médicaments
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Traitement médicamenteux
Type d'étude:
Prognostic_studies
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Screening_studies
Limites du sujet:
Child, preschool
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Humans
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Infant
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Newborn
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Chinese Medical Journal
Année:
2011
Type:
Article