Clinical study on transplantation of G-CSF-mobilized allo-PBSC and allo-bone marrow for leukemia patients / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 326-328, 2005.
Article
Dans Zh
| WPRIM
| ID: wpr-356566
Responsable en Bibliothèque :
WPRO
ABSTRACT
To study clinical outcome of G-CSF-mobilized allo-peripheral blood stem cell (PBSC) and allo-bone marrow (BM) transplantation for patients with leukemia, donors were injected G-CSF 8-10 microg/(kg.d) for 5 days, PBSC were collected on day 4-5 and G-CSF mobilized BM was extracted on day 7. Conditioning regimen consisting of fludarabine, busulfan and cyclophosphamide. The results showed that transplanted cells in all patients were engrafted, the median days of neutrophil exceeding 0.5 x 10(9)/L and platelet exceeding 20 x 10(9)/L were 10.2 days (range 9 - 12 days) and 12.5 days (range 12 - 14 days), respectively. Patients were monitored up to 100 days, 4 of 12 patients (33.3%) developed II aGVHD, 10 of 12 patients (83.3%) developed limited cGVHD. The median follow-up duration was 5 months. Two patients died, the others were alive in disease-free situation. In conclusion, allogeneic transplantation of G-CSF mobilized PBSC plus BM was safe and effective treatment for patients with leukemia, the therapy provides rapid and sustained engraftment without increase in incidence of aGVHt and cGVHD.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Thérapeutique
/
Transplantation homologue
/
Leucémies
/
Chine
/
Études de suivi
/
Facteur de stimulation des colonies de granulocytes
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Transplantation de moelle osseuse
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Résultat thérapeutique
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Mobilisation de cellules souches hématopoïétiques
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Transplantation de cellules souches de sang périphérique
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limites du sujet:
Adolescent
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Adult
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Female
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Humans
/
Male
Pays comme sujet:
Asia
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2005
Type:
Article