Clinicopathologic features and prognostic factors of endometrial stromal sarcoma: a study of 55 cases / 中华病理学杂志
Chinese Journal of Pathology
; (12): 517-522, 2011.
Article
de Zh
| WPRIM
| ID: wpr-358309
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinicopathologic features and the prognostic factors of endometrial stromal sarcoma (ESS).</p><p><b>METHODS</b>55 cases of endometrial stromal sarcoma were reviewed and categorized into 3 pathologic types based on the related literatures, i.e., low grade endometrial stromal sarcoma (LGESS), undifferentiated endometrial sarcoma with nuclear uniformity (UES-U) and undifferentiated endometrial sarcoma with nuclear pleomorphism (UES-P). Meanwhile, the pathologic features were reviewed, including fibroid, myoid, mucoid, and epithelioid differentiation and mitotic index. Clinical and follow-up data were collected.</p><p><b>RESULTS</b>In endometrial stromal sarcoma, two or three pathologic types co-existed in one case, including 12.8% (5/39) of LGESS, 5/9 of UES-U, and 5/7 of UES-P. Mitotic index varied in different regions of one tumor from rare to high. Multi-differentiation was also commonly seen in ESS. The numbers of cases in LGESS, UES-U and UES-P were 39, 9 and 7, with recurrence rate of 51.6% (16/31), 5/6 and 2/3, respectively. There was no death case in LGESS, and 2 cases were died in UES-U and UES-P, respectively. In the 2 death cases of UES-U, both had focus of UES-P. There was a significant difference in the recurrence rate between cases with different mitotic index (≥ 10/10 HPF and < 10/10 HPF, P = 0.009), especially in LGESS group. All death cases had high mitotic index (> 30/10 HPF).</p><p><b>CONCLUSIONS</b>It is a common phenomenon in ESS that two or three pathologic types may exist in one case, especially in UES-U and UES-P. And multi-differentiation is also commonly seen in ESS. So adequate pathologic sampling is important for pathologists to make a correct diagnosis of ESS in daily work. The recurrence rates are significantly higher in cases with high mitotic index, especially in LGESS. In addition, the presence of UES-P and high mitotic index may increase the risk of death in the patients.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Chirurgie générale
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Différenciation cellulaire
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Taux de survie
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Études de suivi
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Classification
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Tumeurs de l'endomètre
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Sarcome du stroma endométrial
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Tumeurs du stroma endométrial
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Hystérectomie
Type d'étude:
Observational_studies
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Prognostic_studies
Limites du sujet:
Adult
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Aged
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Aged80
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Female
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Humans
langue:
Zh
Texte intégral:
Chinese Journal of Pathology
Année:
2011
Type:
Article