Your browser doesn't support javascript.
loading
Preparation and characterization of oxaliplatin-loaded nanostructured lipid carriers / 药学学报
Yao Xue Xue Bao ; (12): 1177-82, 2010.
Article de Zh | WPRIM | ID: wpr-382302
Bibliothèque responsable: WPRO
ABSTRACT
Oxaliplatin-loaded nanostuctured lipid carriers (OP-NLC) were prepared by ultrasonic emulsification method. And its optimal prescription was selected by orthogonal design. The laser light scattering technique, zeta potential analyzer, TEM, DSC, XRD and HPLC were employed to study the physicochemical parameters of OP-NLC, which displayed in terms of particle size, zeta potential, crystalline, drug loading and encapsulation efficiency. The results showed that OP-NLC had an average diameter of (111 +/- 20) nm, zeta potential of (-27.4 +/- 13.1) mV, encapsulation efficiency of (77.4 +/- 2.5) % and drug content of (0.8 +/- 1.5) mg mL(-1). TEM, DSC and XRD indicated that OP-NLC was spherical and the drug was dispersed as nanoparticles by means of non-crystalline. The in vitro release test showed that the drug could be sustained-released from NLC in buffer solution (pH 4.5) after a burst release in initial phase.
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Yao Xue Xue Bao Année: 2010 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Yao Xue Xue Bao Année: 2010 Type: Article