Effects of Aprotinin on the levels of cerebral IL-1β,IL-6 and IL-8 in rats experienced focal cerebral ischemia reperfusion / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 1928-1929, 2009.
Article
Dans Zh
| WPRIM
| ID: wpr-391610
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To observe the protective effect of aprotinin on the cerebral ischemia-reperfusion injury. Methods Rat model of cerebral ischemia-reperfusion injury was created by the middle cerebral artery embolization. The changes of IL-1β,IL-6 and IL-8 content in the brain tissue were measured by ELISA. The neurological scores were made on Zea Longa 5-point scale. Results In model group, the IL-1β,IL-6 and IL-8 protein content began to increase slightly at 3 hours compared with sham group, reached the peal[at 12 hours. In the aprotinin treated group, aprotinin reduced the protein content. It showed no significant difference between model group and aprotinin treated group at 3 hours, however and there was greatly difference at 6,12 and 24 hours between these two groups. Conclusion The present study provides in vivo evidence that aprotinin protects brain against cerebral ischemia-reperfusion injury. The mechanism is related to the decrease of cerebral levels of IL-1β,IL-6 and IL-8.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Prognostic_studies
langue:
Zh
Texte intégral:
Chinese Journal of Primary Medicine and Pharmacy
Année:
2009
Type:
Article