Association study of erythrocytes catechol-O-methyltransferase activity and mood disorders / 中国行为医学科学
Chinese Journal of Behavioral Medical Science
; (6): 625-626, 2005.
Article
de Zh
| WPRIM
| ID: wpr-402018
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To analyse the relationship between catechol-O-methyltransferase (COMT) activity and affective disorders, and explore the biological mechanism of the etiology of affective disorders.Methods The activities of erythrocytes COMT from 112 affective disorders and 120 normal control were measured with high performance liquid chromatography, all examined data were tested by SPSS 11.0v.Results COMT activity frequency distribution of patients group and control group are at the range of 2~23nmol/ml RBC/hr and 7~28nmol/ml RBC/hr respectively. The average activity of COMT in patients group and control group were (11.0±3.8) nmol/ml RBC/hr and (16.1±4.3) nmol/ml RBC/hr representatively. COMT activity in male and female patient were (11.2±3.7) nmol/ml RBC/hr and (10.6± 4.0) nmol/ml RBC/hr., male and female in control group were (16.5 ±4.6) nmol/ml RBC/hr and (15.4±3.9) nmol/ml RBC/hr, there were significant difference between patients group and control group and also between male and female (P <0.001).conclusion The activity of erythrocytes COMT in affective disorders is lower than normal population and suggested that the lower COMT activity of erythrocytes is associated with affective disorders.
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WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Behavioral Medical Science
Année:
2005
Type:
Article