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Effects of UVB and UV-irradiated UCA on the Function of Langerhans' Cell / 中华皮肤科杂志
Article de Zh | WPRIM | ID: wpr-402195
Bibliothèque responsable: WPRO
ABSTRACT
Objective To study the immunosuppression mechanism induced by ultraviolet (UV) and cis-urocanic acid. Method The auto lymphocyte proliferation test with Langerhans' cell (LC) in guinea -pig was performed. Results In exposure to low dose of UVB (25 J/m2) radiation, the inhibition rate of lymphocyte proliferation stimulated by LC was 10. 5%, the inhibition rates of UVB radiation in doses of 50 J/m2 and 100 J/m2 were 22.4% or 50%, respectively. The lymphocyte proliferation was almost completely suppressed by200J/m2 UVB radiation, while the inhibition of LC function by cis-urocanic acid was weak. Conclusion UVB significantly inhibits LC auto -stimulation in dose -dependent way, which may play an important role in UVB induced immunosuppression.
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Chinese Journal of Dermatology Année: 2001 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Chinese Journal of Dermatology Année: 2001 Type: Article