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The relationship between urinary albumin excretion and serum uric acid in general population / 中华内科杂志
Zhonghua Nei Ke Za Zhi ; (12): 550-554, 2011.
Article de Zh | WPRIM | ID: wpr-416945
Bibliothèque responsable: WPRO
ABSTRACT
Objective To investigate the relationship between the urinary albumin excretion (UAE) and serum uric acid in general population. Methods The study participants were derived from the epidemiological study on the association of metabolic syndrome and chronic kidney disease (CKD) in Pinggu district, Beijing. A total of 992 participants (463 men and 529 women) aged from 30 to 75 years were enrolled in this study. For each participant, UAE, serum uric acid, serum creatinine, and serum lipids were detected and other potential risk factors for CKD were surveyed. Results ( 1 ) The frequencies of microalbuminuria, macroalbuminuria and hyperuricemia were 12.9% , 1.8% and 4.3% respectively. The persons with hyperuricemia had significantly higher frequency of albuminuria than those without hyperuricemia (37. 2% vs 13. 7% , P <0. 01). (2) The participants were divided according to the quartiles (25% , 50% , 75% ) of serum uric acid level, and the frequencies of albuminuria in males were 13. 2% , 13. 9% , 17. 2% and 25.4% , while those in females were 8. 4% , 6. 2% , 9. 6% and 24. 8%. ( 3 ) Multivariate logistic regression analysis showed, hyperuricemia was significantly associated with albuminuria in females (OR =2. 31, 95% CI 1. 15-4. 68; P=0.02), but not in males. If the persons with reduced renal function were excluded, similar result still could be gained. Conclusions The prevalence of albuminuria increases gradually with uric acid elevation. Serum uric acid is an independent risk factor of elevated UAE, especially in females.
Mots clés
Texte intégral: 1 Indice: WPRIM Type d'étude: Risk_factors_studies langue: Zh Texte intégral: Zhonghua Nei Ke Za Zhi Année: 2011 Type: Article
Texte intégral: 1 Indice: WPRIM Type d'étude: Risk_factors_studies langue: Zh Texte intégral: Zhonghua Nei Ke Za Zhi Année: 2011 Type: Article