Regulation of cyclin E and cancers / 国际肿瘤学杂志
Journal of International Oncology
; (12): 337-340, 2012.
Article
de Zh
| WPRIM
| ID: wpr-426024
Bibliothèque responsable:
WPRO
ABSTRACT
Cyclin E is expressed starting from the middle G1 phase of the cell cycle,and is accumulated in the G1/S boundry.Cyclin E binds to and activates the cyclin-dependent kinase CDK2.Cyclin E-CDK2 complex initiates a cascade of events that leads to DNA replication by phosphorylating its substrates,such as Rb,CDC6,NPAT and P107,etc.Additionally,cyclin E plays an important role in the regulation of genomic stability,spindle-organizing structure and centrosome cycle.Cyclin E expression is trans-activated by members of the transcription factor E2F family and degrades via the ubiquitin-proteasome pathway.At the same time,it is also negatively regulated by the CIP/KIP proteins.Cyclin E highly expressed in the initiation and progression of different human cancers,such as breast cancers,lung cancers,leukemia,lymphomas and others.
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of International Oncology
Année:
2012
Type:
Article