The effect of p70S6K1 and 4EBP1 protein in colorectal cancer / 国际肿瘤学杂志
Journal of International Oncology
; (12): 392-394, 2015.
Article
de Zh
| WPRIM
| ID: wpr-467325
Bibliothèque responsable:
WPRO
ABSTRACT
The phosphatidylinositide-3-kinase(PI3K)/ protein kinase B(Akt)/ mammalian target of rapamycin(mTOR)pathway is recognized to have an important role in the development and progression of colo-rectal cancer(CRC). The most extensively characterized downstream targets of mTORC1 are ribosomal protein S6 kinase 1(p70S6K1)and eukaryotic translation initiation factor(eIF)4E-binding protein 1(4EBP1),both of which are crucial to the regulation of protein synthesis. The abnormal expression of p70S6K1 and 4EBP1 in CRC has become the focus of attention.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of International Oncology
Année:
2015
Type:
Article