Color Doppler imaging analysis of retrobulbar blood flow velocities in primary open-angle glaucomatous eyes: a meta-analysis / 中华眼底病杂志

ABSTRACT

Objective To observe the hemodynamic parameters of retrobulbar vessels of eyes with primary open-angle glaucoma (POAG) by using color Doppler imaging (CDI) technique.Methods Pertinent publications were retrieved from the PubMed of The National Library of Medicine,the ISI Web of Knowledge of The Institute for Scientific Information,and Cochrane Central Register of Controlled Trials.Case control studies involved POAG patients were included.Changes in retrobulbar blood flow parameters including peak systolic velocity (PSV),end diastolic velocity (EDV) and resistive index (RI) of the ophthalmic artery (OA),central retinal artery (CRA) and short posterior ciliary artery (SPCA) were evaluated by CDI.The searching time was from the data base established up to April,2014.Meta analysis was used on the included articles,the mean difference (MD) along with 95 ％ confidence interval (95 ％ CI) of the blood flow parameters were calculated.Results Twenty-four articles were retrieved,including 1336 eyes as cases,1102 eyes as controls.PSV of POAG eyes was statistically signiflcantly lower than controls in theOA (MD=-3.05,95％CI-4.49--1.61,P＜0.001),CRA (MD=-1.66,95％CI-1.95--1.38,P＜0.001),SPCA (MD=-0.87,95％ CI-1.49--0.26,P=0.005).EDV of POAG eyes was statistically significantly reduced than controls in the OA (MD=-1.78,95％CI-2.14--1.41,P＜0.001),CRA (MD=-0.95,95％CI-1.17--0.74,P＜0.001),SPCA (MD=-0.53,95％CI--0.71--0.36,P＜0.001).Statistically significant increases in RI of POAG eyes than controls in the OA (MD=0.04,95％CI0.03-0.05,P＜0.001),CRA (MD=0.06,95％CI0.05-0.07,P＜0.001),SPCA (MD=0.04,95％CI0.03-0.06,P＜0.001).Conclusion This meta-analysis suggests that significant decreased velocity and increased resistance of retrobulbar blood flow are found in POAG eyes.