Role of transcription factor DEC1 in the initiation and progression of malignant tumors / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 541-547, 2015.
Article
Dans Zh
| WPRIM
| ID: wpr-481938
Responsable en Bibliothèque :
WPRO
ABSTRACT
DEC1 is a basic helix-loop-helix(bHLH)transcription factor involved in the regulation of cell prolif-eration;cell differentiation;lymphocytes maturation;circadian rhythms;immune response and response to hypoxia.Recent studies have revealed that the expression of DEC1 is abnormally high in various tumor tissues and cells.In addition;the expression of DEC1 in the tumor tissue is related to the malignancy of various cancer types.This paper;therefore;focuses on the relationship between DEC1 and proliferation;apoptosis;cellular senes-cence;invasion and metastasis of tumor cells;in order to elaborate the role of DEC1 in the pathogenesis and pro-gression of tumor.
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WPRIM
langue:
Zh
Texte intégral:
Journal of China Pharmaceutical University
Année:
2015
Type:
Article