Meta-analysis of the association between Trp64Arg polymorphism in β3-adrenergic receptor gene and overweight/obesity in children / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 121-124, 2016.
Article
de Zh
| WPRIM
| ID: wpr-488091
Bibliothèque responsable:
WPRO
ABSTRACT
[Summary] In this study, PubMed, Embase, China National Knowledge Infrastructure, databases VIP Chinese Periodical Database, and Wanfang Chinese Periodical Database were systematically searched for the case-control study related β3-adrenergic receptor ( ADRB3 ) Trp64Arg gene polymorphism to overweight/obesity among children from 1962 to 2014.Twelve eligible studies with 2 222 overweight/obese children and 1 955 normal children were included according the uniform inclusion and exclusion criteria.Meta-analyses showed that Trp64Arg polymorphism was associated with significantly increased overweight/obesity risk in Arg carriers among children( OR=1.34,95%CI1.17-1.53).Afterstratificationforethnicity,highlysignificantcoorelationofTrp64Argpolymorphism to overweight/obesity in Asian children(OR=1.44, 95%CI 1.23-1.68) but not significant in Europe(OR=1.05, 95%CI 0.79-1.40).It suggested that Trp64Arg polymorphism is associated with overweight/obesity susceptibility in children.Our results support an strong association between Trp64Arg polymorphism and overweight/obesity among the Asian children investigated.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
langue:
Zh
Texte intégral:
Chinese Journal of Endocrinology and Metabolism
Année:
2016
Type:
Article