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Post-marketing evaluation of the effectiveness and safety of a varicella attenuated live vaccine in ;China / 中华微生物学和免疫学杂志
Article de Zh | WPRIM | ID: wpr-498456
Bibliothèque responsable: WPRO
ABSTRACT
Objective To evaluate the effectiveness and safety of varicella attenuated live vaccine ( VarV) produced by A Co. Ltd. Methods We selected 3 provinces in China and enrolled 15 002 children aged 3-<11 in this random, multicenter study. Participants were randomly divided into two groups: the ex-perimental group and the control group. Every varicella case was collected and recorded to calculate the vac-cine efficacy. Vaccine safety was assessed by means of spontaneous report and regular follow-up visits. Re-sults During the observation period, the incidence of varicella was 0. 147% in the experimental group and 1. 155% in the control group (P<0. 001). The vaccine efficacy was 87. 27%. The adverse reaction rate af-ter vaccination was lower than the rates reported in other literatures. Conclusion The VarV produced by A Co. , Ltd. in China was effective and safe in preventing varicella.
Mots clés
Texte intégral: 1 Indice: WPRIM Type d'étude: Clinical_trials langue: Zh Texte intégral: Chinese Journal of Microbiology and Immunology Année: 2016 Type: Article
Texte intégral: 1 Indice: WPRIM Type d'étude: Clinical_trials langue: Zh Texte intégral: Chinese Journal of Microbiology and Immunology Année: 2016 Type: Article