Recombined adenovirus expressing P53 in the treatment of malignant pleural effusion with lung cancer / 局解手术学杂志
Journal of Regional Anatomy and Operative Surgery
; (6): 192-194, 2015.
Article
Dans Zh
| WPRIM
| ID: wpr-499981
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To assess the therapeutic efficacy of a recombined adenovirus expressing p53 (rAd-p53) via intrapleural injec-tion in the treatment of lung cancer with malignant pleural effusion. Methods Thirty-six cases with lung cancer and malignant pleural effu-sion were randomly divided into two groups,which were given intravenous injection of Nedaplatin with (observation group,n=20) or without (control group,n=16) intrapleural injection of rAd-p53,respectively. Between the two groups,the efficacy in treatment of pleural effusion, the amelioration of maximal ventilatory volume ( MVV) ,Kamofsky scoring ( KPS) and quality of life were compared. Results The efficacy in treatment of pleural effusion in observation group are significantly higher than that in control group(17/20 vs. 50%,P<0. 05). The cases with KPS≥80 in observation group were significantly increased following treatment (5/20 vs. 11/20,P <0. 05). However,there was no difference with the cases in control group. Conclusion Intrapleural injection of recombinant adenovirus expressing p53 (rAd-p53) is effec-tive to reduce the occurrence of malignant pleural effusion and increase the quality of life remarkably.
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WPRIM
langue:
Zh
Texte intégral:
Journal of Regional Anatomy and Operative Surgery
Année:
2015
Type:
Article