Effect of denatonium benzoate on airway inflammation and remodeling in asthmatic mice / 重庆医学
Chongqing Medicine
; (36): 752-754, 2017.
Article
de Zh
| WPRIM
| ID: wpr-509691
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To evaluate the effect of denatonium benzoaten on α-smooth muscle actin (α-SMA),subepithelial collagen and airway inflammation in asthmu mice.Methods Forty-five BALB/c mice were divided into 3 groups,normal control group (A group),asthma model group (B group),asthma model+ denatonium benzoaten group(C group);α-SMA detected by using immunohistochemistry,lung sections were stained with Masson to detect subepithelial collagen,HE stain method was used to observe the airway inflammation the images were analyzed with semi-quantitative computer.Results The deposition of α-SMA、subepithelial collagen and inflammation degree in C group was significantly reduced compared with B group,the difference were statistically significant(P<0.05).Conclusion Denatonium benzoaten can improve airway remodeling in asthmatic mice.
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WPRIM
langue:
Zh
Texte intégral:
Chongqing Medicine
Année:
2017
Type:
Article