Study on Formulation of Xiqingguo Buccal Tablet / 中国药房
China Pharmacy
; (12): 1386-1388, 2017.
Article
Dans Zh
| WPRIM
| ID: wpr-515337
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE:
To study the formulation of Xiqingguo buccal tablet,optimize the proportion and quantity of main materials.METHODS:
Using appearance,hardness,dissolution and taste as investigation indexes,orthogonal design was adopted to optimize the proportion and quantity of main thinner(lactose,mannitol),wetting agent(ethanol),lubricant(magnesium stea-rate),flavoring agent(aspartame),and critical relative humidity was detected.RESULTS:
By wet granulation,the optimal formu-lation were as follows as the ratio of lactose and mannitol was 13,ethanol volume fraction was 60%,the dosage of menthol, magnesium stearate,aspartame and orange essence was 0.4%,0.9%,2.0%,0.4%;it was proven that the total score of 3 batches of samples were 2.67,2.67,2.70 (RSD=0.65%,n=3),respectively. The critical relative humidity of granule was 60%. CON-CLUSIONSThe Xiqingguo buccal tablet prepared by optimal prescription meets the requirements.
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langue:
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Texte intégral:
China Pharmacy
Année:
2017
Type:
Article