Determination of the Potencies of Oxytetracycline Crude Drug and Its Tablets by Turbidimetric Method / 中国药房
China Pharmacy
; (12)1991.
Article
Dans Zh
| WPRIM
| ID: wpr-531772
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE:
To establish a turbidimetric method for the determination of the potency of the crude drugs and tablets of oxytetracycline.METHODS:
By turbidimetric method in which Staphylococcus aureus was used as the test organism with biomass concentration of 1.0%~1.5% (V/V). The culture temperature was 37 ℃ and the culture time was about 4 h. The method was compared with the cup-plate method in potency.RESULTS:
The linear range of oxytetracycline was 0.05~0.4 IU?mL-1. The average recovery of the crude drug of oxytetracycline was 99.59% (RSD=2.0%) and that of oxytetracycline tablets was 99.51% (RSD=1.91%), showing no significant difference as compared with the cup-plate method in contents.CONCLUSIONS:
The method was sensitive and rapid yet with few influencing factors thus applicable for the determination of the potencies of oxytetracycline and its tablets.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
China Pharmacy
Année:
1991
Type:
Article