Detection of alpha-fetoprotein messenger RNA in peripheral blood of patients with hepatocellular carcinoma / 中国现代普通外科进展
Article
Dans Zh
| WPRIM
| ID: wpr-539775
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective:
To determine whether alpha-fetoprotein(AFP) messenger RNA(mRNA),a specifically hepatocyte-expressed gene,could be a marker of metastasis in hepatocellular carcinoma.Methods:
Peripheral blood samples were obtained from 30 patients with hepatocellular carcinoma (HCC).A sensitive reverse transcription polymerase chain reaction( RT-PCR) technique was used to detect the human AFP mRNA in the blood.Results:
Of the 30 HCC patients,14(46.7%) patients had positive AFP mRNA.The presence of AFP mRNA correlated with the TNM clinical stages,the size of tumor,extrahepatic metastasis or with portal vein carcinothrombosis(P0.05).Conclusion:
The positive of AFP mRNA in the peripheral blood can indicate the presence of hematogenous metastasis in patients with HCC.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Diagnostic_studies
langue:
Zh
Texte intégral:
Chinese Journal of Current Advances in General Surgery
Année:
1999
Type:
Article