Effect of Dichlorvos and Omethoate Exposure on Sperm Abnormality in Mice / 环境与健康杂志

ABSTRACT

Objective To explore the effect of dichlorvos and omethoate exposure on reproductive cells of male animals and to provide the scientific evidence for the integrated precaution and protective measure of the agricultural byproduct pollution.Methods 42 male Kunming mice were randomly divided into 7 groups,6 in each group.The 6 groups were dichlorvos and omethoate treated groups,the other was the control group.The mice were treated with dichlorvos or omethoate for 21 consecutive days by gavage,dichlorvos doses were at of 5.0,10.0 and 20.0 mg/kg,omethoate doses were at of 2.5,5.0 and 10.0 mg/kg respectively,the mice in the control group were given physiological saline by gavage at the same volume.The changes of frequency on the sperm abnormality were examined after 21 days.Results Compared with the control group,the frequency of the sperm abnormality in each treated group increased significantly(P