Prediction of the epitopes on HA of avian influenza virus(H5N1) / 中国免疫学杂志

ABSTRACT

Objective:To search for common epitopes of(H5N1) from different areas in the world in order to develope epitope-bacterin by the way of immunoinformatics.Methods:Firstly,homologous degree of the amino acid sequence of VIA from different areas was compared on the basis of the database in Genebank with soft-ware ClustalW1.83.The common epitopes which were able to bind strongly to MHCⅠ molecule were selected.Results:Though homologous degree of amino acid sequence of VIA from different areas was not completely similar,there were some common epitopes among these strains analyzed.The common epitopes were shown to bind strongly with MHCⅠ molecule.Conclusion:These common epitopes may be used to develope epitope-bacterin for preventing infection of AIV(H5N1).