Your browser doesn't support javascript.
loading
RELATION OF ANTIRADIATION EFFECT OF LAMINARIA JAPONICA POLYSACCHARIDES AND LYMPHOCYTE APOPTOSIS / 营养学报
Article de Zh | WPRIM | ID: wpr-555828
Bibliothèque responsable: WPRO
ABSTRACT
Objective:To investigate the relation of antiradiation effect of LJP and lymphocyte apoptosis. Methods:36 Wistar rats were randomly divided into 6 groups (n=6): control, model,and LJP given i.g.at 4 doses(100,200,300,400 mg/ kg bw) for 10d before whole-body irradiation with 9.0 Gy Co?-ray. 18h later,the effects of LJP on the indices of immune function of the irradiated rats 60 were measured. TUNEL and flow cytometry were used to study the effects of LJP on splenic lymphocyte apoptosis and immunohistochemical technique was used to detect the expression of Bcl-2 and the Bax protein. Results:LJP significantly modulated immune function in irradiated rats. The apoptosis ratio of splenic lymphocyte of the model group was higher than those of other groups. LJP could markedly inhibit the effects of irradiation on apoptosis and increase the ratio of bcl-2/bax protein in dose-effect manner. Conclusion:LJP could inhibit splenic lymphocyte apoptosis induced by irradiation, and its mechanism is associated with regulating the expression of bcl-2 and bax protein of splenic lymphocyte. Key word:laminaria japonica polysaccharides; irradiation; lymphocyte; apoptosis apoptosis-related genes
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Acta Nutrimenta Sinica Année: 2004 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Acta Nutrimenta Sinica Année: 2004 Type: Article