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Overexpression of the epithelial cell adhesion molecule is associated with a more favorable prognosis and response to platinum-based chemotherapy in ovarian cancer / 부인종양
Article de En | WPRIM | ID: wpr-55731
Bibliothèque responsable: WPRO
ABSTRACT
OBJECTIVE: Epithelial cell adhesion molecule (EpCAM) has experienced a renaissance lately as a binding site for targeted therapy as well as a prognostic marker in epithelial malignancies. Aim of this study was to study EpCAM as a potential prognostic marker in epithelial ovarian cancer (EOC). METHODS: EpCAM expression was assessed by immunohistochemistry on paraffin-embedded primary EOC-tissue samples. EpCAM overexpression was defined as an expression of EpCAM of 76% to 100%. Tissue samples and clinical data were systematically collected within the international and multicenter "Tumorbank Ovarian Cancer" network. RESULTS: Seventy-four patients, diagnosed with EOC between 1994 and 2009, were included in the study (median age, 56 years; range, 31 to 86 years). The majority of the patients (81.1%) presented with an advanced stage International Federation of Gynecology and Obstetrics (FIGO) III/IV disease. Histology was of the serous type in 41 patients (55.4%), endometrioid in 19 (25.6%), and mucinous in 14 (19%). EpCAM was overexpressed in 87.7%. Serous tumors overexpressed EpCAM significantly more often than mucinous tumors (87.8% vs. 78.6%, p=0.045); while no significant difference was noted between the other histological subgroups. EpCAM overexpression was significantly associated with a better progression free survival and higher response rates to platinum based chemotherapy (p=0.040 and p=0.048, respectively). EpCAM was identified as an independent prognostic marker for overall survival (p=0.022). CONCLUSION: Our data indicate a significant association of EpCAM overexpression with a more favorable survival in EOC-patients. Serous cancers showed a significant EpCAM overexpression compared to mucinous types. Larger multicenter analyses are warranted to confirm these findings.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Composés organiques du platine / Tumeurs de l'ovaire / Pronostic / Banques de tissus / Marqueurs biologiques tumoraux / Molécules d'adhérence cellulaire / Carboplatine / Résultat thérapeutique / Paclitaxel / Tumeurs épithéliales épidermoïdes et glandulaires Type d'étude: Clinical_trials / Prognostic_studies Limites du sujet: Adult / Aged / Aged80 / Female / Humans langue: En Texte intégral: Journal of Gynecologic Oncology Année: 2014 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Composés organiques du platine / Tumeurs de l'ovaire / Pronostic / Banques de tissus / Marqueurs biologiques tumoraux / Molécules d'adhérence cellulaire / Carboplatine / Résultat thérapeutique / Paclitaxel / Tumeurs épithéliales épidermoïdes et glandulaires Type d'étude: Clinical_trials / Prognostic_studies Limites du sujet: Adult / Aged / Aged80 / Female / Humans langue: En Texte intégral: Journal of Gynecologic Oncology Année: 2014 Type: Article