Inhibitory effect of celebrex on the VX_2 renal carcinoma in rabbit model / 解放军医学杂志

ABSTRACT

Objective To evaluate the effect of the cyclooxygenase (COX-2) inhibitor celebrex on the growth of VX_2 renal carcinoma in a rabbit model in order to provide the basis for clinical application. Methods A rabbit model of VX_2 renal carcinoma was reproduced. The effect of COX-2 inhibitor celebret on tumor growth was observed. Results Compared with control, the growth of VX_2 renal carcinoma was remarkably retarded after celebrex treatment for 2 and 3 weeks. The difference between the two groups was signiticant (P