Effects of Combined Telmisartan and Ramipril on Heart Function and Renin-angiotensin-aldosterone System and Ventricle Remodeling in Patients with Chronic Congestive Heart Failure / 医学研究杂志

ABSTRACT

Objective To study the effects of combined telmisartan and ramipril on heart function and renin-angiotensin-aldosterone system and ventricle remodeling and brain natriuretic peptide in patients with chronic heart failure(CHF).Methods 100 patients with chronic heart failure were randomly divided into three groups: telmisartan group(A group,treated with telmisartan 80mg once daily,n=33),ramipril group(B group treated with ramipril 5mg once daily,n=33) and telmisartan plus ramipril group(treated with telmisartan 40mg plus ramipril 2.5mg once daily,n=34).Left ventricular end-diastolic dimensions(LVEDD) and left ventricular ejection fraction(LVEF) were assessed,and plasma renin activity(Ren),angiotensinII(AngII),aldosterone(Ald) and brain natriuretic peptide(BNP) were measured before and after therphy.Results After 6 months of treatment,LVEDD and LVEF were improved in all groups(P0.01).The concentration of Ald and BNP was decreased in all groups(P