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Effect of NVP-AAM077 and Ro25-6981 on hippocampal neuronal injury and brain derived neurotrophic factor expression in global cerebral ischemic mice / 中国药理学通报
Article de Zh | WPRIM | ID: wpr-568110
Bibliothèque responsable: WPRO
ABSTRACT
Aim The aim of the present study is to in-vestigate the effect of the specific antagonist NVP-AAM077 and Ro25-6981 of NMDA receptor subunit NR2A and NR2B on global cerebral ischemia-induced neuronal injury in the CA1 region. Methods Male C57BL/6 mice subjected to global ischemia by the three-vessel occlusion( 3-VO) method,were divided into four groups: sham-operated group,ischemia/reperfusion control group,NVP-AAM077 treatment group,and Ro25-6981 treatment group. Hippocampal sections were processed for Fluoro-Jade B staining to detect degenerating neurons and for Nissl staining to identify surviving neurons. The expression of brain derived neurotrophic factor( BDNF) were measured by Western blot. Results ① Transient brain ischemia induced selective and delayed neuron death in the CA1 region of the hippocampus at 12-minute ischemia after reperfusion 3 days. NR2A subtype specific antagonist NVP-AAM077 enhanced neuronal death after transient global ischemia ( P
Mots clés
Texte intégral: 1 Indice: WPRIM Type d'étude: Prognostic_studies langue: Zh Texte intégral: Chinese Pharmacological Bulletin Année: 2003 Type: Article
Texte intégral: 1 Indice: WPRIM Type d'étude: Prognostic_studies langue: Zh Texte intégral: Chinese Pharmacological Bulletin Année: 2003 Type: Article