Effects of Insulin-like Growth Factor-Ⅰ and Insulin-like Growth Factor Binding-protein 1 on Development of Ovarian Follicles during Superovulation Cycle / 中华妇产科杂志
Chinese Journal of Obstetrics and Gynecology
; (12)2000.
Article
Dans Zh
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| ID: wpr-569681
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To investigate the effects of insulin-like growth factor Ⅰ (IGF-Ⅰ) and insulin-like growth factor binding-protein 1 (IGFBP-1) on development of ovarian follicles during gonadotropin stimulation in in-vitro fertilization (IVF) program. Methods Enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay were used to determine the levels of IGF-Ⅰ, IGFBP-1 and estradiol (E 2) in serum and follicular fluid obtained during oocyte pick-up (OPU) in 32 IVF-embryo transfer cycles. Results (1) Serum IGFBP-1 levels increased with growth of follicles [(3 5?1 0) ?g/L during OPU, (2 1?0 5) ?g/L before stimulation, P 0 05]. Significant positive correlation was found between serum IGFBP-1 and serum E 2 [(3 5?1 0) ?g/L, (3 293? 1 361) pmol/L, r =0 41, P
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Obstetrics and Gynecology
Année:
2000
Type:
Article