Synergistic Action of Zicao Tianhuafen Decoction and Mifepristone on Abortion / 广州中医药大学学报

ABSTRACT

[Objective] To observe the effect of Zicao Tianhuafen Decoction (ZTD), mainly composed of Radix Arnebiae seu Lithospermi, Radix Trichosanthis, Rhizoma Bletillae, Radix Notoginseng and Radix Codonopsis Pilosulae, on abortion induced by mifepristone. [Methods] One hundred and sixty cases were randomly allocated to two groups. After administration of mifepristone in the two groups, Group A was given ZTD while Group B was not. Complete abortion rate, incomplete abortion rate, ineffective rate, vaginal bleeding volume and bleeding time were observed after treatment. [Results] The complete abortion rate was 96.25% in Group A and 86.25% in Group B (P = 0.058). Vaginal bleeding volume was less and bleeding time shorter in Group A than those in Group B(P = 0.001). [Conclusion] ZTD can decrease the vaginal bleeding volume and shorten the bleeding time and tends to increase the complete abortion rate.