Rat model of abdominal aortic banding and its clinical significance / 重庆医科大学学报

ABSTRACT

Objective:To establish rat model of ventricular hypertrophy and heart failure by partially banding abdominal aorta for different time limits.Methods:60 Wistar rats were randomly divided into three groupsA group which were ligated for 4 weeks;B group being ligated for 8 weeks;and sham-operated group (each containing 20 Wistar rats).Left and right ventricular mass index,hemodynamic parameters,cardiac morphological changes and the time of achieving heart failure model were investigated in different groups.Results:There were 16.67% heart failure rats in A group,while 73.68% in B group.The death of models occurred in the first week after experimental procedure.MBP and LVSP were increased greatly in A group,and HR,MBP,LVSP and ?dp/dt were decreased while LVEDP increased in B group compared with A and sham-operated groups( P