Correlation of Serum High-mobility Group Box Protein 1 Level with Defense-Qi-nutrient-blood Syndrome Differentiation and Acute Physiological and Chronic Health Evaluation Ⅱ Score in Sepsis Patients / 广州中医药大学学报

ABSTRACT

Objective To investigate the serum high-mobility group box protein 1(HMGB1)level in sepsis patients with different syndrome patterns,and to explore the correlation of HMGB1 level with defense-Qi-nutrient-blood syndrome differentiation and Acute Physiological and Chronic Health Evaluation Ⅱ(APACHEⅡ)score.Methods Twenty-four sepsis patients were differentiated as Qi system syndrome(QS group,N=11)and nutrient-blood system syndrome(NB group,N=13).Eight healthy volunteers served as the normal control.APACHEⅡ score was evaluated,serum HMGB1 level was detected by Western blot method,and the correlation of HMGB1 level with defense-Qi-nutrient-blood syndrome differentiation and APACHEⅡ score was analyzed.Results APACHEⅡ score was higher in NB group than that in QS group,the difference being significant(P