Histopathological changes of bowenoid papulosis and its relationship with apopotosis / 吉林大学学报(医学版)

ABSTRACT

Objective To study the histopathological changes and biological behavior of bowenoid papulosis and its relationship with apopotosis.Methods 20 bowenoid papuloses and 5 normal skin tissues were examined by DNA nick end labeling(TUNEL) technique and the pathological changes of bowenoid papulosis were observed by Hematoxylin-eosin-stained.Results Bowenoid papulosis exhibited disordered maturation and scattered,large,highly atypical cells mitoses throughout all layers of epithelium;and there were few apoptotic cells in 5 normal skin tissuese and many apoptotic cells in bowenoid papuloses.The apoptotic index(27.1?15.1) in bowenoid papulosis patients was significantly higher than that in control group(6.8?3.5)(P