Effect of simvastatin on NF-kappa B p65 expression in liver of insulin resistant rats / 中国糖尿病杂志
Chinese Journal of Diabetes
; (12)2008.
Article
de Zh
| WPRIM
| ID: wpr-592203
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To study the effect of simvastatin(SV) on NF-kappa B p65 expression in liver of insulin resistant rats. Methods Male Wistar rats were divided into two groups:basic chow(NC,n=15)or high-fat diet(HF,n=20)for 10 weeks feeding, then assessed by euglycemic-hyperinsulinemia clamp technique. Rats in HF group were treated with(HFS,n=5)and without (HFN,n=5) SV 10mgkg-1d-1 in gavage for 5 weeks.NF-kappa B p65 expressions were tested with Western blot. Results The glucose infusion rate (GIR) in HF group decreased significantly compared with NC group (P
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Diabetes
Année:
2008
Type:
Article