Effect of 17β-estradiol on idiopathic ventricular arrhythmia and IP3/Ryn 2 expression of receptor-regulated calcium pool during peri-menopausal period / 中国生化药物杂志
Chinese Journal of Biochemical Pharmaceutics
; (6): 145-146,150, 2017.
Article
de Zh
| WPRIM
| ID: wpr-606364
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To observe the curative effect of 17β-estradiol on idiopathic ventricular arrhythmia (IVA) during peri-menopausal period and explore the association with IP3/Ryn expression of receptor-regulated calcium pool. Methods 32 cases IVA during peri-menopausal period (IVA group) and 32 cases healthy women during peri-menopausal period of the same levels of age (normal control group) were selected. The IVA group received oral 17β-estradiol for 2 months. The count of arrhythmia in IVA group was recorded, the IP3/Ryn 2 expression pre- and post-treatment in IVA group and normal control group were detected. Results Compared with pre-treatment, 17β-estradiol significantly reduced the occurrence of IVA (P<0.05). Compared with pre-treatment, 17β-estradiol significantly reduced IP3 expression(P<0.05), while there was no significant difference compared with normal control group. 17β-estradiol had no significant effect on Ryn 2 expression. Conclusion The anti-IVA effect of 17β-estradiol may be associated with the IP3 receptor gene expression.
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Biochemical Pharmaceutics
Année:
2017
Type:
Article