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Plasma neutrophil gelatinase-associated lipocalin as a potential predictor of adverse renal outcomes in immunoglobulin A nephropathy
Article de En | WPRIM | ID: wpr-63000
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND/AIMS: Neutrophil gelatinase-associated lipocalin (NGAL) is a well-known biomarker of acute kidney injury. We evaluated the value of plasma NGAL (pNGAL) as an independent predictor of prognosis in immunoglobulin A nephropathy (IgAN). METHODS: In total, 91 patients with biopsy-proven IgAN at a single center were evaluated. pNGAL was measured using a commercial enzyme-linked immunosorbent assay kit (R&D Systems). Adverse renal outcome was defined as chronic kidney disease (CKD) stage 3 or above at the last follow-up. Pearson correlation coefficient and Cox regression were used for analyses. RESULTS: The mean age of all patients (male:female, 48:43) was 35 years (range, 18 to 77). pNGAL ranged between 21.68 and 446.40 ng/mL (median, 123.97) and showed a correlation with age (r = 0.332, p = 0.001), creatinine (r = 0.336, p = 0.001), estimated glomerular filtration rate (r = -0.397, p 1 g/day (HR, 5.184; 95% CI, 1.124 to 23.921; p = 0.035), and pNGAL (HR, 1.012; 95% CI, 1.003 to 1.022; p = 0.013) were independent predictors associated with adverse renal outcome. CONCLUSIONS: pNGAL showed strong correlations with other clinical prognostic factors and was also an independent predictor of adverse renal outcome. We suggest pNGAL as a potential predictor for prognosis in IgAN, while further studies are needed to confirm the clinical value.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Facteurs temps / Biopsie / Protéine de la phase aigüe / Test ELISA / Marqueurs biologiques / Loi du khi-deux / Modèles linéaires / Modèles des risques proportionnels / Analyse multifactorielle Type d'étude: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Adolescent / Adult / Aged / Female / Humans / Male Pays comme sujet: Asia langue: En Texte intégral: The Korean Journal of Internal Medicine Année: 2015 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Facteurs temps / Biopsie / Protéine de la phase aigüe / Test ELISA / Marqueurs biologiques / Loi du khi-deux / Modèles linéaires / Modèles des risques proportionnels / Analyse multifactorielle Type d'étude: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Adolescent / Adult / Aged / Female / Humans / Male Pays comme sujet: Asia langue: En Texte intégral: The Korean Journal of Internal Medicine Année: 2015 Type: Article