Research progress of SlRT1 as a target for the treatment of age - related retinal disease / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 233-237, 2015.
Article
de Zh
| WPRIM
| ID: wpr-637173
Bibliothèque responsable:
WPRO
ABSTRACT
Silent information regulator protein 1 (SlRT1) is one of the sirtuins and belongs to histone deacetyase. lts activity depends on nicotinamide adenine dinucleotide ( NAD+) and is regulated by NAD+. Experimental and clinical studies have shown the neuro-protective effect of SlRT1 in the pathogenesis of age-related eye diseases. ln this review, the relationship between SlRT1 activator and apoptosis in the retinal cells were discussed. The review also points to SlRT1 as a potential therapeutic target for the clinical management of age-related retinal disease.
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WPRIM
langue:
Zh
Texte intégral:
International Eye Science
Année:
2015
Type:
Article