Immunophenotypic Features of NK/T Cell Lymphoma in Children and Its Association with Epstein-Barr Virus / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)1993.
Article
Dans Zh
| WPRIM
| ID: wpr-639078
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To study the immunophenotypic features of NK/T cell lymphoma in children and its association with Epstein-Barr virus (EBV) infection. Methods Five cases of children′s NK/T cell lymphoma were studied. CD45RO, CD3?, CD56, CD20, TIA-1 and granzyme B were detected by immunohistochemistry staining for investigating immunophenotype. The expression of EBV-latent membrane protein (LMP-1) were detected by immunohistochemistry. EBV-encoded RNA (EBER1/2) were detected by in situ hybridization (ISH). Results CD45RO, CD3?, TIA-1 and granzyme B were positive in 5 cases, CD56 was positive in 2 cases, while CD20 negative in 5 cases.EBER1/2 positive in 4 cases and LMP-1 positive in 3 cases.Conclusions NK/T cell lymphoma in children is strong associated with EBV infection,and EBV infection may play an important role in the pathogenesis of children NK/T cell lymphoma.
Texte intégral:
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Applied Clinical Pediatrics
Année:
1993
Type:
Article