Epidemiology and Clinical Characteristics of Childhood Acute Lymphoblastic Leukemia in Korea / 대한소아혈액종양학회지
Korean Journal of Pediatric Hematology-Oncology
; : 9-20, 2002.
Article
Dans Ko
| WPRIM
| ID: wpr-64468
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE:
Acute lymphoblastic leukemia (ALL) accounts for approximately 75% of all cases of childhood leukemia. We investigated epidemiology, clinical and laboratory features and treatment outcome of the children with ALL in Korea during recent 5 years.METHODS:
One thousand forty nine patients were enrolled between January 1994 and December 1998 from 37 major hospitals in Korea. The data regarding the clinical and laboratory features including age, WBC counts at diagnosis, immunophenotype, morphology, cytogenetics and treatment outcome of patients were analyzed retrospectively by review of patient's medical records. Kaplan-Meier survival curves were constructed. The differences between groups analyzed by log-rank test.RESULTS:
There were 597 males and 452 females. The distribution between the age 2 and 5 years is most common in 46.1%. The annual incidence rate per 100,000 population varied from 1.6 to 2.2. The 5 year event free survival (EFS) rates according to good prognostic factors were as follows 67% bet ween 1-9 year of age at diagnosis, 69% in under 10,000/mm3of initial WBC count, 74% in early pre-B cell CALLA ( ) immunophenotype, 65% in L3 morphology, 68% in no CNS invasion. Most of patients were treated by CCG treatment protocol. The 5 year EFS was 63%. Main complications were sepsis (21.8%) and hemorrhage (12.5%). The relapse rate was 15.6%. The common causes of death were sepsis, DIC, pneumonia, relapse.CONCLUSION:
Our results could provide the most recent and important information about acute lymphoblastic leukemia of children in Korea.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pneumopathie infectieuse
/
Récidive
/
Leucémies
/
Protocoles cliniques
/
Dossiers médicaux
/
Épidémiologie
/
Incidence
/
Études rétrospectives
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Cause de décès
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Résultat thérapeutique
Type d'étude:
Diagnostic_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limites du sujet:
Child
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Female
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Humans
/
Male
Pays comme sujet:
Asia
langue:
Ko
Texte intégral:
Korean Journal of Pediatric Hematology-Oncology
Année:
2002
Type:
Article